mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3- mutated acute myeloid leukemia cells
Abstract Activating mutations of the FLT3 gene mediate leukemogenesis, at least in part, through activation of PI3K/AKT. The mammalian target of rapamycin (mTOR)-Raptor signaling pathway is known to act downstream of AKT. Here we show that the mTOR effectors, 4EBP1, p70S6K and rpS6, are highly activ...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Saesneg |
| Cyhoeddwyd: |
2010
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| Mynediad Ar-lein: | https://doi.org/10.1186/1476-4598-9-292 https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-292 |
| Tagiau: |
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