Reduction in Mitochondrial Superoxide Dismutase Modulates Alzheimer's Disease-Like Pathology and Accelerates the Onset of Behavioral Changes in Human Amyloid Precursor Protein Transgenic Mice
Alzheimer's disease (AD) is associated with accumulations of amyloid-β (Aβ) peptides, oxidative damage, mitochondrial dysfunction, neurodegeneration, and dementia. The mitochondrial antioxidant manganese superoxide dismutase-2 (Sod2) might protect against these alterations. To test this hypothe...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2006
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| 在线阅读: | https://doi.org/10.1523/jneurosci.0482-06.2006 https://www.jneurosci.org/content/jneuro/26/19/5167.full.pdf |
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