Soluble Ig-Like Transcript 3 Inhibits Tumor Allograft Rejection in Humanized SCID Mice and T Cell Responses in Cancer Patients

Soluble Ig-Like Transcript 3 Inhibits Tumor Allograft Rejection in Humanized SCID Mice and T Cell Responses in Cancer Patients

Abstract Attempts to enhance patients’ immune responses to malignancies have been largely unsuccessful. We now describe an immune-escape mechanism mediated by the inhibitory receptor Ig-like transcript 3 (ILT3) that may be responsible for such failures. Using a humanized SCID mouse model, we demonst...

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Main Authors: Nicole Suciu‐Foca, Nikki Feirt, Qing-Yin Zhang, George Vlad, Zhuoru Liu, Hana Lin, Chih‐Chao Chang, Eric Ho, Adriana I. Colovai, Howard L. Kaufman, Vivette D. D’Agati, Harshwardhan M. Thaker, Helen Remotti, Sara Galluzzo, P Cinti, Carla Rabitti, John Allendorf, John A. Chabot, Marco Caricato, Roberto Coppola, P.B. Berloco, Raffaello Cortesini
Format: Artigo
Language:English
Published: 2007
Online Access:https://doi.org/10.4049/jimmunol.178.11.7432
https://journals.aai.org/jimmunol/article-pdf/178/11/7432/1232176/zim01107007432.pdf
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https://doi.org/10.4049/jimmunol.178.11.7432
https://journals.aai.org/jimmunol/article-pdf/178/11/7432/1232176/zim01107007432.pdf

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