Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis.
The murine TNF-alpha gene was expressed under the control of the human surfactant protein SP-C promoter in transgenic mice. A number of the SP-C TNF-alpha mice died at birth or after a few weeks with very severe lung lesions. Surviving mice transmitted a pulmonary disease to their offspring, the sev...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
1995
|
| Online adgang: | https://doi.org/10.1172/jci118029 http://www.jci.org/articles/view/118029/files/pdf |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|