Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation–differentiation balance early in life and optic nerve degeneration at old age

Exome sequencing and functional analyses suggest that SIX6 is a gene involved in an altered proliferation–differentiation balance early in life and optic nerve degeneration at old age

Primary open-angle glaucoma (POAG) is a hereditary neurodegenerative disease, characterized by optic nerve changes including increased excavation, notching and optic disc hemorrhages. The excavation can be described by the vertical cup–disc ratio (VCDR). Previously, genome-wide significant evidence...

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Hlavní autoři: Adriana I. Iglesias, Henriët Springelkamp, Herma van der Linde, Lies‐Anne Severijnen, Najaf Amin, Ben A. Oostra, Christel Kockx, Mirjam C. G. N. van den Hout, Wilfred F. J. van IJcken, Albert Hofman, André G. Uitterlinden, Robert M. Verdijk, Caroline C. W. Klaver, Rob Willemsen, Cornelia M. van Duijn
Médium: Artigo
Jazyk:angličtina
Vydáno: 2013
On-line přístup:https://doi.org/10.1093/hmg/ddt522
https://academic.oup.com/hmg/article-pdf/23/5/1320/14142472/ddt522.pdf
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https://doi.org/10.1093/hmg/ddt522
https://academic.oup.com/hmg/article-pdf/23/5/1320/14142472/ddt522.pdf

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