The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration
WWOX, encoding WW domain-containing oxidoreductase, spans FRA16D, the second most common chromosomal fragile site frequently altered in cancers. It is therefore considered a tumor suppressor gene, but its direct implication in cancerogenesis remains controversial. By whole-exome sequencing, we ident...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2014
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| Accés en línia: | https://doi.org/10.1186/1750-1172-9-12 https://ojrd.biomedcentral.com/counter/pdf/10.1186/1750-1172-9-12 |
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