The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway

ABSTRACT Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67tm1Dgen...

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Hlavní autoři: Zakia A. Abdelhamed, Subaashini Natarajan, Gabrielle Wheway, C.F. Inglehearn, Carmel Toomes, Colin A. Johnson, Daniel J. Jagger
Médium: Artigo
Jazyk:angličtina
Vydáno: 2015
On-line přístup:https://doi.org/10.1242/dmm.019083
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https://doi.org/10.1242/dmm.019083

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