EDEM1 accelerates the trimming of 1,2-linked mannose on the C branch of N-glycans
Glycoprotein folding and degradation in the endoplasmic reticulum (ER) is mediated by the ER quality control system. Mannose trimming plays an important role by forming specific N-glycans that permit the recognition and sorting of terminally misfolded conformers for ERAD (ER-associated degradation)....
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2010
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| 在線閱讀: | https://doi.org/10.1093/glycob/cwq001 https://academic.oup.com/glycob/article-pdf/20/5/567/5845559/cwq001.pdf |
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