Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy
The EGF receptor gene (EGFR) is most frequently amplified and overexpressed, along with its deletion mutant, EGFRvIII, in glioblastoma. We tested the preclinical efficacy of the recombinant immunotoxin, D2C7-(scdsFv)-PE38KDEL, which is reactive with a 55-amino acid (AA) region present in the extrace...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2013
|
| Online adgang: | https://doi.org/10.1158/1078-0432.ccr-12-3891 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|