Molecular Characterization of <i>Helicobacter pylori</i> VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-κB Activation

Molecular Characterization of <i>Helicobacter pylori</i> VacA Induction of IL-8 in U937 Cells Reveals a Prominent Role for p38MAPK in Activating Transcription Factor-2, cAMP Response Element Binding Protein, and NF-κB Activation

Abstract Helicobacter pylori VacA induces multiple effects on susceptible cells, including vacuolation, mitochondrial damage, inhibition of cell growth, and enhanced cyclooxygenase-2 expression. To assess the ability of H. pylori to modulate the production of inflammatory mediators, we examined the...

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Principais autores: Junzo Hisatsune, Masaaki Nakayama, Hajime Isomoto, Hisao Kurazono, Naofumi Mukaida, Asish K. Mukhopadhyay, Takeshi Azuma, Yoshio Yamaoka, Jan Sap, Eiki Yamasaki, Kinnosuke Yahiro, Joel Moss, Toshiya Hirayama
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Acesso em linha:https://doi.org/10.4049/jimmunol.180.7.5017
https://journals.aai.org/jimmunol/article-pdf/180/7/5017/1259164/zim00708005017.pdf
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https://doi.org/10.4049/jimmunol.180.7.5017
https://journals.aai.org/jimmunol/article-pdf/180/7/5017/1259164/zim00708005017.pdf

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