Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers

Amplification of <i>CRKL</i> Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non–Small Cell Lung Cancers

We previously identified a region of recurrent amplification on chromosome 22q11.21 in a subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor protein, is amplified and overexpressed in non-small cell lung cancer (NSCLC) cells that harbor 22q11.21 amplifications. Ov...

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Main Authors: Hiu Wing Cheung, Jinyan Du, Jesse S. Boehm, Frank He, Barbara A. Weir, Xiaoxing Wang, Mohit Butaney, Lecia V. Sequist, Biao Luo, Jeffrey A. Engelman, David E. Root, Matthew Meyerson, Todd R. Golub, Pasi A. Jänne, William C. Hahn
Format: Artigo
Language:English
Published: 2011
Online Access:https://doi.org/10.1158/2159-8290.cd-11-0046
https://cancerdiscovery.aacrjournals.org/content/candisc/1/7/608.full.pdf
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https://doi.org/10.1158/2159-8290.cd-11-0046
https://cancerdiscovery.aacrjournals.org/content/candisc/1/7/608.full.pdf

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