An MRAS, SHOC2, and SCRIB Complex Coordinates ERK Pathway Activation with Polarity and Tumorigenic Growth

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• SHOC2–MRAS–PP1 complex positively regulates RAF activity and contributes to Noonan syndrome pathogenesis
  per: Lucy C. Young, et al.
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• Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome
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