Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
Senescence may function as a two-edged sword that brings unexpected consequences to organisms. Here we provide evidence to support this theory by showing that the absence of the Brca1 full-length isoform causes senescence in mutant embryos and cultured cells as well as aging and tumorigenesis in adu...
Uloženo v:
| Hlavní autoři: | , , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2003
|
| On-line přístup: | https://doi.org/10.1101/gad.1050003 http://genesdev.cshlp.org/content/17/2/201.full.pdf |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|