Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
Senescence may function as a two-edged sword that brings unexpected consequences to organisms. Here we provide evidence to support this theory by showing that the absence of the Brca1 full-length isoform causes senescence in mutant embryos and cultured cells as well as aging and tumorigenesis in adu...
Sábháilte in:
| Príomhchruthaitheoirí: | , , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Béarla |
| Foilsithe / Cruthaithe: |
2003
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| Rochtain ar líne: | https://doi.org/10.1101/gad.1050003 http://genesdev.cshlp.org/content/17/2/201.full.pdf |
| Clibeanna: |
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