Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen
The canonical Wnt signaling pathway, mediated by the transcription factor β-catenin, plays critical roles in embryonic development and represents an important therapeutic target. In a zebrafish-based in vivo screen for small molecules that specifically perturb embryonic dorsoventral patterning, we d...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | engleski |
| Izdano: |
2013
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| Online pristup: | https://doi.org/10.1016/j.celrep.2013.07.047 |
| Oznake: |
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