Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
Chronic (5-16 hr) exposure of cultured human lymphocytes to 10 -8 M insulin at 37° in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. These results reproduced observations in vivo where chronic hyp...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
1974
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| Acesso em linha: | https://doi.org/10.1073/pnas.71.1.84 |
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