TNF‐α‐mediated reduction in PGC‐1α may impair skeletal muscle function after cigarette smoke exposure
Abstract Skeletal muscle dysfunction contributes to exercise limitation in COPD. In this study cigarette smoke exposure was hypothesized to increase expression of the inflammatory cytokine, TNF‐α, thereby suppressing PGC‐1α, and hence affecting down stream molecules that regulate oxygen transport an...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2009
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| 在線閱讀: | https://doi.org/10.1002/jcp.21955 |
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