Targeting the Mitogen-Activated Protein Kinase Pathway: Physiological Feedback and Drug Response
Abstract Mitogen-activated protein kinase (MAPK) pathway activation is a frequent event in human cancer and is often the result of activating mutations in the BRAF and RAS oncogenes. Targeted inhibitors of BRAF and its downstream effectors are in various stages of preclinical and clinical developmen...
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| Autori principali: | , |
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| Natura: | Revisão |
| Lingua: | inglese |
| Pubblicazione: |
2010
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| Accesso online: | https://doi.org/10.1158/1078-0432.ccr-09-3064 https://aacrjournals.org/clincancerres/article-pdf/16/13/3329/1990448/3329.pdf |
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