A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Heterochromatin in aging stem cells Analysis of human aging syndromes, such as Werner syndrome (WS), may lead to greater understanding of both premature and normal aging. Zhang et al. generated isogenic WS-specific human embryonic stem cell lines (see the Perspective by Brunauer and Kennedy). WS-mes...

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Main Authors: Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, Jing Qu, Ping Wang, Junzhi Zhou, Xiaomeng Liu, Ruotong Ren, Xiuling Xu, Alejandro Ocampo, Tingting Yuan, Jiping Yang, Ying Li, Liang Shi, Dee Guan, Huize Pan, Shunlei Duan, Zhichao Ding, Mo Li, Fei Yi, Ruijun Bai, Yayu Wang, Chang Chen, Fuquan Yang, Xiaoyu Li, Zimei Wang, Emi Aizawa, April Goebl, Rupa Devi Soligalla, Pradeep Reddy, Concepción Rodrı́guez Esteban, Fuchou Tang, Guang‐Hui Liu, Juan Carlos Izpisúa Belmonte
Format: Artigo
Language:English
Published: 2015
Online Access:https://doi.org/10.1126/science.aaa1356
https://www.science.org/cms/asset/fb9ebf23-4648-4533-ac16-ba2ad3db5ea7/pap.pdf
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https://doi.org/10.1126/science.aaa1356
https://www.science.org/cms/asset/fb9ebf23-4648-4533-ac16-ba2ad3db5ea7/pap.pdf

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