KCC2 activity is critical in limiting the onset and severity of status epilepticus

Significance Status epilepticus (SE) is defined as a state of continuous unremitting seizures that often exhibits underlying deficits in neuronal inhibition mediated by GABA A receptors. The efficacy of neuronal inhibition is critically dependent on the activity of the K + /Cl – cotransporter KCC2,...

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Autori principali: Liliya Silayeva, Tarek Z. Deeb, Rochelle M. Hines, Matt R. Kelley, Michaelanne B. Munoz, Henry H.C. Lee, Nicholas J. Brandon, John Dunlop, Jaime L. Maguire, Paul Davies, Stephen J. Moss
Natura: Artigo
Lingua:inglese
Pubblicazione: 2015
Accesso online:https://doi.org/10.1073/pnas.1415126112
https://www.pnas.org/content/pnas/112/11/3523.full.pdf
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