p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death

The p53 tumor suppressor gene has been implicated in the regulation of apoptosis in a number of different neuronal death paradigms. Because of the importance of p53 in neuronal injury, we questioned the mechanism underlying p53-mediated apoptosis in neurons. Using adenoviral-mediated gene delivery,...

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Main Authors: Sean P. Cregan, Nicole Arbour, Jason G. MacLaurin, Steven M. Callaghan, Andre Fortin, Eric C. Cheung, Daniel S. Guberman, David S. Park, Ruth S. Slack
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Acesso em linha:https://doi.org/10.1523/jneurosci.2114-04.2004
https://www.jneurosci.org/content/jneuro/24/44/10003.full.pdf
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