Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection

Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection

Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodie...

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Main Authors: Dipak Kumar Raj, Christian P. Nixon, Christina E. Nixon, Jeffrey D. Dvorin, Christen G. DiPetrillo, Sunthorn Pond‐Tor, Hai-Wei Wu, Grant Jolly, Lauren Pischel, Ailin Lu, Ian C. Michelow, Ling Cheng, Solomon Conteh, Emily A. McDonald, Sabrina Absalon, Sarah Holte, Jennifer F. Friedman, Michal Fried, Patrick E. Duffy, Jonathan D. Kurtis
Format: Artigo
Language:English
Published: 2014
Online Access:https://doi.org/10.1126/science.1254417
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https://doi.org/10.1126/science.1254417

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