Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection

Antibodies to PfSEA-1 block parasite egress from RBCs and protect against malaria infection

Novel vaccines are urgently needed to reduce the burden of severe malaria. Using a differential whole-proteome screening method, we identified Plasmodium falciparum schizont egress antigen-1 (PfSEA-1), a 244-kilodalton parasite antigen expressed in schizont-infected red blood cells (RBCs). Antibodie...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Dipak Kumar Raj, Christian P. Nixon, Christina E. Nixon, Jeffrey D. Dvorin, Christen G. DiPetrillo, Sunthorn Pond‐Tor, Hai-Wei Wu, Grant Jolly, Lauren Pischel, Ailin Lu, Ian C. Michelow, Ling Cheng, Solomon Conteh, Emily A. McDonald, Sabrina Absalon, Sarah Holte, Jennifer F. Friedman, Michal Fried, Patrick E. Duffy, Jonathan D. Kurtis
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2014
Mynediad Ar-lein:https://doi.org/10.1126/science.1254417
Tagiau: Ychwanegu Tag
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https://doi.org/10.1126/science.1254417

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