Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors

Contribution of Toll-like Receptor 9 Signaling to the Acute Inflammatory Response to Nonviral Vectors

Immunostimulatory CpG motifs have been implicated as a major contributor to the acute inflammatory response associated with nonviral vectors, most prominently seen after systemic delivery of cationic lipid-plasmid DNA (pDNA) complexes. We have shown previously that complexes containing pDNA vectors...

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Hlavní autoři: Hongmei Zhao, Hiraoki Hemmi, Shizuo Akira, Seng H. Cheng, Ronald K. Scheule, Nelson S. Yew
Médium: Artigo
Jazyk:angličtina
Vydáno: 2004
On-line přístup:https://doi.org/10.1016/j.ymthe.2003.11.012
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https://doi.org/10.1016/j.ymthe.2003.11.012

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