Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases

Identification of the Sites of Tau Hyperphosphorylation and Activation of Tau Kinases in Synucleinopathies and Alzheimer’s Diseases

ObjectiveMost neurodegenerative diseases contain hyperphosphorylated Tau [p-Tau]. We examined for the first time epitopes at which Tau is hyperphosphorylated in Parkinson’s disease, dementia with Lewy bodies and Alzheimer’s disease, and also select Tau kinases. MethodsPostmortem frontal cortex from...

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Hlavní autoři: Valeriy Duka, Jae‐Hoon Lee, Joel J. Credle, Jonathan Wills, Adam W. Oaks, Ciaran Smolinsky, Ketul Shah, Deborah C. Mash, Eliezer Masliah, Anita Sidhu
Médium: Artigo
Jazyk:angličtina
Vydáno: 2013
On-line přístup:https://doi.org/10.1371/journal.pone.0075025
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075025&type=printable
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https://doi.org/10.1371/journal.pone.0075025
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0075025&type=printable

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