Selecting Aptamers for a Glycoprotein through the Incorporation of the Boronic Acid Moiety
The first general method for the selection of boronic acid−based aptamers (boronolectins) that allows for glycan substructure focusing is described. Using fibrinogen as a model glycoprotein, we have selected boronic acid-modified DNA aptamers that have high affinities (low nM Kd) and the ability to...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2008
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| Accès en ligne: | https://doi.org/10.1021/ja801510d |
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