Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

Mining a Cathepsin Inhibitor Library for New Antiparasitic Drug Leads

The targeting of parasite cysteine proteases with small molecules is emerging as a possible approach to treat tropical parasitic diseases such as sleeping sickness, Chagas' disease, and malaria. The homology of parasite cysteine proteases to the human cathepsins suggests that inhibitors origina...

Full description

Saved in:
Bibliographic Details
Main Authors: Kenny K. H. Ang, Joseline Ratnam, Jiří Gut, Jennifer Legac, Elizabeth Hansell, Zachary B. Mackey, Katarzyna M. Skrzypczynska, Anjan Debnath, Juan C. Engel, Philip J. Rosenthal, James H. McKerrow, Michelle R. Arkin, Adam R. Renslo
Format: Artigo
Language:English
Published: 2011
Online Access:https://doi.org/10.1371/journal.pntd.0001023
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001023&type=printable
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pntd.0001023
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001023&type=printable

Similar Items