Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

DNA gyrase is an essential enzyme in bacteria, and its inhibition results in the disruption of DNA synthesis and, subsequently, cell death. The pyrrolamides are a novel class of antibacterial agents targeting DNA gyrase. These compounds were identified by a fragment-based lead generation (FBLG) appr...

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Autores principales: Ann E. Eakin, Oluyinka Green, Neil J. Hales, Grant K. Walkup, Shanta Bist, Alok Singh, G. B. MULLEN, Joanna Bryant, Kevin J. Embrey, Ning Gao, Alexander L. Breeze, Dave Timms, Beth Andrews, Maria Uria-Nickelsen, Julie Demeritt, James T. Loch, Ken Hull, April Blodgett, Ruth Illingworth, Bryan Prince, P. Ann Boriack‐Sjodin, Sheila I. Hauck, Lawrence MacPherson, Haihong Ni, Brian Sherer
Formato: Artigo
Lenguaje:inglés
Publicado: 2011
Acceso en línea:https://doi.org/10.1128/aac.05485-11
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https://doi.org/10.1128/aac.05485-11

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