Xenobiotic-Induced Hepatocyte Proliferation Associated with Constitutive Active/Androstane Receptor (CAR) or Peroxisome Proliferator-Activated Receptor α (PPARα) Is Enhanced by Pregnane X Receptor (PXR) Activation in Mice
Xenobiotic-responsive nuclear receptors pregnane X receptor (PXR), constitutive active/androstane receptor (CAR) and peroxisome proliferator-activated receptor α (PPARα) play pivotal roles in the metabolic functions of the liver such as xenobiotics detoxification and energy metabolism. While CAR or...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | английский |
| Опубликовано: |
2013
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| Online-ссылка: | https://doi.org/10.1371/journal.pone.0061802 https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0061802&type=printable |
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