Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

Aim of the study To evaluate the frequency of MRE11/RAD50/NBS1 (MRN)-complex loss of protein expression in endometrial cancers (EC) and to determine whether loss of MRE11 renders the cancer cells sensitive to Poly(ADP-ribose) polymerase (PARP)-inhibitory treatment. Methods MRN expression was examine...

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Autori principali: Romana Koppensteiner, Eleftherios P. Samartzis, Aurelia Noske, Adriana von Teichman, Ioannis Dedes, Myriam Gwerder, Patrick Imesch, Kristian Ikenberg, Holger Moch, Daniel Fink, Manuel Stucki, Konstantin J. Dedes
Natura: Artigo
Lingua:inglese
Pubblicazione: 2014
Accesso online:https://doi.org/10.1371/journal.pone.0100041
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100041&type=printable
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Accesso online

https://doi.org/10.1371/journal.pone.0100041
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100041&type=printable

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