Succinate Dehydrogenase-Deficient GISTs
Most gastrointestinal stromal tumors (GISTs) are driven by KIT or PDGFRA-activating mutations, but a small subset is associated with loss of function of the succinate dehydrogenase (SDH) complex of mitochondrial inner membrane proteins. This occurs by germline mutations of the SDH subunit genes and...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2011
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| Acceso en línea: | https://doi.org/10.1097/pas.0b013e3182260752 |
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