A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for <i>Helicobacter pylori</i>

A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for <i>Helicobacter pylori</i>

Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of the enzyme-inhibitor complex reveals the mechanism of inhi...

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Main Authors: Shanzhi Wang, Antti M. Haapalainen, Funing Yan, Quan Du, Peter C. Tyler, Gary B. Evans, Agnes Rinaldo-Matthis, Rosemary L. Brown, Gillian E. Norris, Steven C. Almo, Vern L. Schramm
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1021/bi3009664
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https://doi.org/10.1021/bi3009664

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