A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for <i>Helicobacter pylori</i>
Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of the enzyme-inhibitor complex reveals the mechanism of inhi...
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Autori principali: | , , , , , , , , , , |
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Natura: | Artigo |
Lingua: | inglese |
Pubblicazione: |
2012
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Accesso online: | https://doi.org/10.1021/bi3009664 |
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