4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a nucleoside analog that, unlike approved anti-human immunodeficiency virus type 1 (HIV-1) nucleoside reverse transcriptase inhibitors, has a 3′-OH and exhibits remarkable potency against wild-type and drug-resistant HIVs. EFdA triphosphate (EFdA-TP) i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Eleftherios Michailidis, Andrew D. Huber, Emily Ryan, Yee Tsuey Ong, Maxwell D. Leslie, Kayla B. Matzek, Kamalendra Singh, Bruno Marchand, Ariel N. Hagedorn, Karen A. Kirby, Lisa C. Rohan, Eiichi Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos
Formato: Artigo
Lenguaje:inglés
Publicado: 2014
Acceso en línea:https://doi.org/10.1074/jbc.m114.562694
http://www.jbc.org/article/S0021925820319864/pdf
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doi.org/10.1074/jbc.m114.562694
http://www.jbc.org/article/S0021925820319864/pdf

Ejemplares similares