Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

A large protein complex consisting of Atg5, Atg12 and Atg16L1 has recently been shown to be essential for the elongation of isolation membranes (also called phagophores) during mammalian autophagy. However, the precise function and regulation of the Atg12–5-16L1 complex has largely remained unknown....

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Bibliographic Details
Main Authors: Koutaro Ishibashi, Naonobu Fujita, Eiko Kanno, Hiroko Omori, Tamotsu Yoshimori, Takashi Itoh, Mitsunori Fukuda
Format: Artigo
Language:English
Published: 2011
Online Access:https://doi.org/10.4161/auto.7.12.18025
https://www.tandfonline.com/doi/pdf/10.4161/auto.7.12.18025?needAccess=true
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