3′-Deoxy-3′-[18F]Fluorothymidine Positron Emission Tomography Is a Sensitive Method for Imaging the Response of BRAF-Dependent Tumors to MEK Inhibition
Abstract Activating mutations of BRAF occur in ∼7% of all human tumors and in the majority of melanomas. These tumors are very sensitive to pharmacologic inhibition of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK), which causes loss of D-cyclin expression, hypop...
में बचाया:
| मुख्य लेखकों: | , , , , , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | अंग्रेज़ी |
| प्रकाशित: |
2007
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| ऑनलाइन पहुंच: | https://doi.org/10.1158/0008-5472.can-07-2976 https://aacrjournals.org/cancerres/article-pdf/67/23/11463/2576077/11463.pdf |
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