Protein tyrosine phosphatase activity in the neural crest is essential for normal heart and skull development
Mutations within the protein tyrosine phosphatase, SHP2, which is encoded by PTPN11 , cause a significant proportion of Noonan syndrome (NS) cases, typically presenting with both cardiac disease and craniofacial abnormalities. Neural crest cells (NCCs) participate in both heart and skull formation,...
Збережено в:
| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Англійська |
| Опубліковано: |
2009
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| Онлайн доступ: | https://doi.org/10.1073/pnas.0902230106 |
| Теги: |
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