Hierarchical order of phosphorylation events commits Cdc25A to Beta-TrCP-dependent degradation

We have recently demonstrated that regulation of Cdc25A protein abundance during S phase and in response to DNA damage is mediated by SCF(betaTrCP) activity. Based on sequence homology of known betaTrCP substrates, we found that Cdc25A contains a conserved motif (DSG), phosphorylation of which is re...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Maddalena Donzelli, Luca Busini, Massimo Chiesa, Dvora Ganoth, Avram Hershko, Giulio Draetta
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2004
Mynediad Ar-lein:https://doi.org/10.4161/cc.3.4.770
https://www.tandfonline.com/doi/pdf/10.4161/cc.3.4.770?needAccess=true
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