Gating charge interactions with the S1 segment during activation of a Na <sup>+</sup> channel voltage sensor

Voltage-gated Na + channels initiate action potentials during electrical signaling in excitable cells. Opening and closing of the pore of voltage-gated ion channels are mechanically linked to voltage-driven outward movement of the positively charged S4 transmembrane segment in their voltage sensors....

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Main Authors: Paul G. DeCaen, Vladimir Yarov‐Yarovoy, Todd Scheuer, William A. Catterall
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Acesso em linha:https://doi.org/10.1073/pnas.1116449108
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