Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene encoding the ALK tyrosine kinase receptor predispose for NB. Here, we focus on the normal function of Alk signaling in the...

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Autori principali: Tobias Reiff, Leslie Huber, Marco Krämer, Olivier Delattre, Isabelle Janoueix‐Lerosey, Hermann Rohrer
Natura: Artigo
Lingua:inglese
Pubblicazione: 2011
Accesso online:https://doi.org/10.1242/dev.072157
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