Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42
Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross β-sheet structure, where main chain hydrogen bonding occurs between β-strands in the direction of the fibril axis. The surface of the β-sheet has pronounced ridges and grooves w...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
2006
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| Online-Zugang: | https://doi.org/10.1021/bi052485f |
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