Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria

IDE (insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that has been shown to regulate both cerebral amyloid β-peptide and plasma insulin levels in vivo. Genetic linkage and allelic association have been reported between the IDE gene locus and both late-onset Alzheimer's dis...

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Main Authors: Malcolm A. Leissring, Wesley Farris, Xining Wu, Danos C. Christodoulou, Marcia C. Haigis, Leonard Guarente, Dennis J. Selkoe
格式: Artigo
语言:英语
出版: 2004
在线阅读:https://doi.org/10.1042/bj20041081
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