Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria
IDE (insulin-degrading enzyme) is a widely expressed zinc-metallopeptidase that has been shown to regulate both cerebral amyloid β-peptide and plasma insulin levels in vivo. Genetic linkage and allelic association have been reported between the IDE gene locus and both late-onset Alzheimer's dis...
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Main Authors: | , , , , , , |
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格式: | Artigo |
语言: | 英语 |
出版: |
2004
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在线阅读: | https://doi.org/10.1042/bj20041081 |
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