Loss of PTEN is associated with elevated EGFR and HER2 expression and worse prognosis in salivary gland cancer

Activity of the tumour-suppressor gene PTEN is reduced in different types of cancer and implicates non-responsiveness to targeted therapy. This study evaluates the gene and protein status of PTEN in salivary gland carcinomas.A total of 287 carcinomas of the major and minor salivary glands were inves...

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Bibliographic Details
Main Authors: Tobias Ettl, Katharina Baader, Clemens Stiegler, Melanie Müller, Abbas Agaimy, Johannes Zenk, Thomas Kühnel, Martin Gosau, Katharina Zeitler, Stephan Schwarz, Gero Brockhoff
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1038/bjc.2011.605
https://www.nature.com/articles/bjc2011605.pdf
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