Linear DNAs Concatemerize in Vivo and Result in Sustained Transgene Expression in Mouse Liver
The short duration of transgene expression remains a major obstacle for the implementation of nonviral DNA vectors in clinical gene therapy trials. Here, we demonstrate stable, long-term transgene expression in vivo by transfecting a linear DNA expression cassette (LDNA) into mouse liver. Interestin...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2001
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| 在线阅读: | https://doi.org/10.1006/mthe.2001.0278 https://www.cell.com/article/S1525001601902783/pdf |
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