Linear DNAs Concatemerize in Vivo and Result in Sustained Transgene Expression in Mouse Liver
The short duration of transgene expression remains a major obstacle for the implementation of nonviral DNA vectors in clinical gene therapy trials. Here, we demonstrate stable, long-term transgene expression in vivo by transfecting a linear DNA expression cassette (LDNA) into mouse liver. Interestin...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | İngilizce |
| Baskı/Yayın Bilgisi: |
2001
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| Online Erişim: | https://doi.org/10.1006/mthe.2001.0278 https://www.cell.com/article/S1525001601902783/pdf |
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