Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
Abstract Purpose: Metastatic uveal melanoma represents the most common intraocular malignancy with very poor prognosis and no effective treatments. Oncogenic mutations in the G-protein α-subunit q and 11 have been described in about 85% of uveal melanomas and confer constitutive activation. Multiple...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2012
|
| 在線閱讀: | https://doi.org/10.1158/1078-0432.ccr-11-3086 https://clincancerres.aacrjournals.org/content/clincanres/18/13/3552.full.pdf |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|