Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance
Abstract Purpose: Metastatic uveal melanoma represents the most common intraocular malignancy with very poor prognosis and no effective treatments. Oncogenic mutations in the G-protein α-subunit q and 11 have been described in about 85% of uveal melanomas and confer constitutive activation. Multiple...
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| Glavni autori: | , , , , , , |
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| Format: | Artigo |
| Jezik: | engleski |
| Izdano: |
2012
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| Online pristup: | https://doi.org/10.1158/1078-0432.ccr-11-3086 https://clincancerres.aacrjournals.org/content/clincanres/18/13/3552.full.pdf |
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