A Conserved Alternative Splice in the von Recklinghausen Neurofibromatosis (<i>NF1</i>) Gene Produces Two Neurofibromin Isoforms, Both of Which Have GTPase-Activating Protein Activity

A Conserved Alternative Splice in the von Recklinghausen Neurofibromatosis (<i>NF1</i>) Gene Produces Two Neurofibromin Isoforms, Both of Which Have GTPase-Activating Protein Activity

Sequence analysis has shown significant homology between the catalytic regions of the mammalian ras GTPase-activating protein (GAP), yeast Ira1p and Ira2p (inhibitory regulators of the RAS-cyclic AMP pathway), and neurofibromin, the protein encoded by the NF1 gene. Yeast expression experiments have...

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Principais autores: Lone B. Andersen, Roymarie Ballester, Douglas A. Marchuk, Eric C. Chang, David H. Gutmann, Ann M. Saulino, Jacques Camonis, Michael Wigler, Francis S. Collins
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Acesso em linha:https://doi.org/10.1128/mcb.13.1.487-495.1993
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https://doi.org/10.1128/mcb.13.1.487-495.1993

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