B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions

Abstract Although B7 on APCs has a well-recognized role in T cell costimulation, little is known about the functional significance of constitutive and activation-induced B7 expression that also occurs on T cells. To analyze the role of B7 on T cells, B7-1/B7-2-deficient mice (B7 double knockout) and...

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主要な著者: Patricia A. Taylor, Christopher J. Lees, Sylvie Fournier, James P. Allison, Arlene H. Sharpe, Bruce R. Blazar
フォーマット: Artigo
言語:英語
出版事項: 2004
オンライン・アクセス:https://doi.org/10.4049/jimmunol.172.1.34
https://journals.aai.org/jimmunol/article-pdf/172/1/34/1177937/34.pdf
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