Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Treatment regimens for acute myeloid leukemia (AML) continue to offer weak clinical outcomes. Through a high-throughput cell-based screen, we identified avocatin B, a lipid derived from avocado fruit, as a novel compound with cytotoxic activity in AML. Avocatin B reduced human primary AML cell viabi...

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Библиографические подробности
Главные авторы: Eric A. Lee, Leonard Angka, Sarah-Grace Rota, Thomas Hanlon, Andrew Mitchell, Rose Hurren, Xiao Ming Wang, Marcela Gronda, Ezel Boyacı, Barbara Bojko, Mark D. Minden, Shrivani Sriskanthadevan, Alessandro Datti, Jeffery L. Wrana, Andrea N. Edginton, Janusz Pawliszyn, Jamie W. Joseph, Joe Quadrilatero, Aaron D. Schimmer, Paul A. Spagnuolo
Формат: Artigo
Язык:английский
Опубликовано: 2015
Online-ссылка:https://doi.org/10.1158/0008-5472.can-14-2676
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Internet

https://doi.org/10.1158/0008-5472.can-14-2676

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